Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation.

ABSTRACT:

Objectives

The molecular mechanisms underlying post-operative pericardial adhesions remain poorly understood. We aimed to unveil the temporal molecular and cellular mechanisms underlying tissue dynamics during adhesion formation, including inflammation, angiogenesis, and fibrosis.

Methods and results

We visualized cell-based tissue dynamics during pericardial adhesion using histological evaluations. To determine the molecular mechanism, RNA-seq was performed. Chemical inhibitors were administered to confirm the molecular mechanism underlying adhesion formation. A high degree of adhesion formation was observed during the stages in which collagen production was promoted. Histological analyses showed that arterioles excessively sprouted from pericardial tissues after the accumu

SUBMITTER: Namiguchi K 

PROVIDER: S-EPMC8852280 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature