Sex-specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury.

ABSTRACT: Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by activation in glial cells in various pain-related regions within the central nervous system. Recent studies have suggested a sexually dimorphic role of microglia in the maintenance of neuropathic pain in rodents. Here, we utilized RNA sequencing analysis and in vitro primary cultures of microglia to identify whether there is a common neuropathic microglial signature and characterize the sex differences in microglia in pain-related regions in nerve injury and chemotherapy-induced peripheral neuropathy mouse models. While mechanical allodynia and behavioral changes were observed in all models, transcriptomic analysis of microglia revealed no common transcriptional changes in spinal and supraspinal regio

SUBMITTER: Fiore NT 

PROVIDER: S-EPMC8852349 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature