Circulating Liver-enriched Antimicrobial Peptide-2 Decreases During Male Puberty.

ABSTRACT:

Context

Circulating levels of liver-enriched antimicrobial peptide 2 (LEAP2), a ghrelin receptor antagonist, decrease under caloric restriction and increase in obesity. The role of LEAP2 in male puberty, a phase with accelerated energy demand, is unclear.

Objective

This work aimed to investigate whether circulating LEAP2 levels are downregulated in boys following the onset of puberty to respond to the energy need required for growth.

Methods

We determined circulating LEAP2 levels in 28 boys with constitutional delay of growth and puberty (CDGP) who participated in a randomized controlled trial (NCT01797718), and were treated with letrozole (n = 15) or intramuscular low-dose testosterone (T) (n = 13) for 6 months. Blood sampling and dual-energy x-ray absorptiometry-mea

SUBMITTER: Varimo T 

PROVIDER: S-EPMC8852683 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature