Dataset Information

Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves.

ABSTRACT:

Objective

The aim of this study is to evaluate the differences in clinical presentations and the impact of healthcare organization on outcomes of neurological COVID-19 patients admitted during the first and second pandemic waves.

Methods

In this single-center cohort study, we included all patients with SARS-CoV-2 infection admitted to a Neuro-COVID Unit. Demographic, clinical, and laboratory data were compared between patients admitted during the first and second waves of the COVID-19 pandemic.

Results

Two hundred twenty-three patients were included, of whom 112 and 111 were hospitalized during the first and second pandemic waves, respectively. Patients admitted during the second wave were younger and exhibited pulmonary COVID-19 severity, resulting in less oxygen support (n = 41, 36.9% vs n = 79, 70.5%, p < 0.001) and lower mortality rates (14.4% vs 31.3%, p = 0.004). The different healthcare strategies and early steroid treatment emerged as significant predictors of mortality independently from age, pre-morbid conditions and COVID-19 severity in Cox regression analyses.

Conclusions

Differences in healthcare strategies during the second phase of the COVID-19 pandemic probably explain the differences in clinical outcomes independently of disease severity, underlying the importance of standardized early management of neurological patients with SARS-CoV-2 infection.

SUBMITTER: Cristillo V

PROVIDER: S-EPMC8852998 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves.

Cristillo Viviana V Pilotto Andrea A Benussi Alberto A Libri Ilenia I Giunta Marcello M Morotti Andrea A Gipponi Stefano S Locatelli Martina M Piccinelli Stefano Cotti SC Mazzoleni Valentina V di Cola Francesca Schiano FS Masciocchi Stefano S Pezzini Debora D Scalvini Andrea A Premi Enrico E Cottini Elisabetta E Gamba Massimo M Magoni Mauro M Fontanella Marco Maria MM Padovani Alessandro A

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20220217 5

<h4>Objective</h4>The aim of this study is to evaluate the differences in clinical presentations and the impact of healthcare organization on outcomes of neurological COVID-19 patients admitted during the first and second pandemic waves.<h4>Methods</h4>In this single-center cohort study, we included all patients with SARS-CoV-2 infection admitted to a Neuro-COVID Unit. Demographic, clinical, and laboratory data were compared between patients admitted during the first and second waves of the COVI ...[more]

PMID: 35175442

Similar Datasets

Project description:BackgroundThe COVID-19 pandemic has led to huge pressure on not only healthcare systems, but also on healthcare professionals.ObjectiveAs the pandemic continues, the aim of this study is to evaluate how 10 reactions of healthcare professionals evolved during the first 18 months of COVID-19.MethodsA repeated cross-sectional study was performed with eight measurement points between April 2020 and September 2021 in Belgium. Participants were asked how frequently (on a scale of 0-10) they experienced positive and negative reactions during normal circumstances and during past week, referred to as before and during COVID-19, respectively. These reactions were stress, fatigue, difficulty sleeping, muscle strain, hypervigilance, leaving profession, headache, doubting knowledge and skills, flashbacks and fear.ResultsIn total, 13 308 respondents were included in our study. During both the first (March 2020) and second COVID-19 peak (November 2020), the measured personal, professional and physical reactions were significantly higher compared to before COVID-19. The third wave in April 2021 was shorter and less severe with regard to hospital admissions and deaths, yet an important impact on healthcare professionals could still be observed. 'Fatigue,' 'stress,' 'difficulty sleeping' and 'muscle strain' are the most worrying reactions in September 2021, which are increasing compared to the previous measurements.ConclusionOur results showed that acute stress reactions decreased over time but that chronic stress reactions and professional reactions, such as 'intent to leave,' increased. Healthcare organizations and policy makers should realize that 18 months after the start of COVID-19 almost all of the measured reactions continue to be more prevalent than before COVID-19. Moreover, the continuous increase over the last three measurement periods of the number of healthcare professionals who want to leave their profession is alarming. Continuous follow-up of the personal, professional and physical reactions is more than necessary.

Dataset Information

Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves.

Objective

Methods

Results

Conclusions

Publications

Clinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets