Characterising ¹⁸F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging.

ABSTRACT:

Background

¹⁸F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of ¹⁸F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades.

Methods

Thirty-nine patients with pathologically proven breast cancer underwent 20-min dynamic PET/computed tomography imaging following the administration of ¹⁸F-fluciclovine. Uptake into primary breast tumours was evaluated using one- and two-tissue reversible compartmental kinetic models and static parameters.

Results

A reversible one-tissu

SUBMITTER: Scott NP 

PROVIDER: S-EPMC8854436 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature