Tractography dissection variability: What happens when 42 groups dissect 14 white matter bundles on the same dataset?

ABSTRACT: White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways, which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography, including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human whole-brain streamlines and asked to segment

SUBMITTER: Schilling KG 

PROVIDER: S-EPMC8855321 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature