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Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats.


ABSTRACT: Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. By utilizing gas exchange manipulations and optogenetics in the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide, suggesting that seizure-generating circuits are sensitive to pH. Moreover, hyperventilation consistently activated neurons within the intralaminar nuclei of the thalamus, a structure implicated in seizure generation. We show that intralaminar thalamus also contains pH-sensitive neurons. Collectively, these observations suggest that hyperventilation activates pH-sensitive neurons of the intralaminar nuclei to provoke absence seizures.

SUBMITTER: Salvati KA 

PROVIDER: S-EPMC8860449 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats.

Salvati Kathryn A KA   Souza George M P R GMPR   Lu Adam C AC   Ritger Matthew L ML   Guyenet Patrice P   Abbott Stephen B SB   Beenhakker Mark P MP  

eLife 20220104


Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. By utilizing gas exchange manipulations and optogenetics in the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide, suggesting that seizure-gene  ...[more]

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