Ontology highlight
ABSTRACT:
SUBMITTER: Salvati KA
PROVIDER: S-EPMC8860449 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Salvati Kathryn A KA Souza George M P R GMPR Lu Adam C AC Ritger Matthew L ML Guyenet Patrice P Abbott Stephen B SB Beenhakker Mark P MP
eLife 20220104
Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. By utilizing gas exchange manipulations and optogenetics in the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide, suggesting that seizure-gene ...[more]