The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk.

ABSTRACT:

Background

We aimed to understand host factors that affect discriminatory performance of a transcriptomic signature of tuberculosis risk (RISK11).

Methods

HIV-negative adults aged 18-60 years were evaluated in a prospective study of RISK11 and surveilled for tuberculosis through 15 months. Generalised linear models and receiver-operating characteristic (ROC) regression were used to estimate effect of host factors on RISK11 score (%marginal effect) and on discriminatory performance for tuberculosis disease (area under the curve, AUC), respectively.

Findings

Among 2923 participants including 74 prevalent and 56 incident tuberculosis cases, percentage marginal effects on RISK11 score were increased among those with prevalent tuberculosis (+18·90%, 95%CI 12·66-25·13), nig

SUBMITTER: Mulenga H 

PROVIDER: S-EPMC8861653 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature