An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.

ABSTRACT: Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during treatment. To support the development of methods for identifying these mechanisms in individual people, here we present an omic and multidimensional spatial (OMS) atlas generated from four serial biopsies of an individual with metastatic breast cancer during 3.5 years of therapy. This resource links detailed, longitudinal clinical metadata that includes treatment times and doses, anatomic imaging, and blood-based response measurements to clinical and exploratory analyses, which includes comprehensive DNA, RNA, and protein profiles; images of multiplexed immunostaining; and 2- and 3-dimensional scanning electron micrographs. These data

SUBMITTER: Johnson BE 

PROVIDER: S-EPMC8861971 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature