Unknown

Dataset Information

0

Evidence for infection in intervertebral disc degeneration: a systematic review.


ABSTRACT:

Purpose

Back pain is a major problem worldwide and is linked to intervertebral disc degeneration and Modic change. Several studies report growth of bacteria following extraction of degenerate discs at spine surgery. A pathophysiological role for infection in back pain has been proposed.

Method

We conducted a PRISMA systematic review. MEDLINE, PubMed, Scopus and Web of Science were searched with the terms Modic change, intervertebral dis*, bacteria, microb*, and infect*. Date limits of 2001-2021 were set. Human studies investigating the role of bacteria in disc degeneration or Modic change in vertebrae were included.

Results

Thirty-six articles from 34 research investigations relating to bacteria in human degenerate discs were found. Cutibacterium acnes was identified in pathological disc material. A 'candidate bacterium' approach has been repeatedly adopted which may have biased results to find species a priori, with disc microbial evidence heavily weighted to find C. acnes.

Conclusion

Evidence to date implicates C. acnes identified through culture, microscopy and sequencing, with some suggestion of diverse bacterial colonisation in the disc. This review found studies which used culture methods and conventional PCR for bacterial detection. Further agnostic investigation using newer methods should be undertaken.

SUBMITTER: Granville Smith I 

PROVIDER: S-EPMC8873132 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Evidence for infection in intervertebral disc degeneration: a systematic review.

Granville Smith Isabelle I   Danckert Nathan P NP   Freidin Maxim B MB   Wells Philippa P   Marchesi Julian R JR   Williams Frances M K FMK  

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20211204 2


<h4>Purpose</h4>Back pain is a major problem worldwide and is linked to intervertebral disc degeneration and Modic change. Several studies report growth of bacteria following extraction of degenerate discs at spine surgery. A pathophysiological role for infection in back pain has been proposed.<h4>Method</h4>We conducted a PRISMA systematic review. MEDLINE, PubMed, Scopus and Web of Science were searched with the terms Modic change, intervertebral dis*, bacteria, microb*, and infect*. Date limit  ...[more]

Similar Datasets

2024-04-05 | GSE230809 | GEO
| PRJNA962588 | ENA
| S-EPMC6512192 | biostudies-literature
| S-EPMC7667735 | biostudies-literature
| S-EPMC10041387 | biostudies-literature
| S-EPMC9251272 | biostudies-literature
| S-EPMC9863885 | biostudies-literature
| S-EPMC6223888 | biostudies-literature
| S-EPMC7846842 | biostudies-literature
| S-EPMC7139977 | biostudies-literature