The role of EP₂ receptors in mediating the ultra-long-lasting intraocular pressure reduction by JV-GL1.

ABSTRACT:

Background

A single application of JV-GL1 substantially lowers non-human primate intraocular pressure (IOP) for about a week, independent of dose. This highly protracted effect does not correlate with its ocular biodisposition or correlate with the once-daily dosing regimen for other prostanoid EP₂ receptor agonists such as trapenepag or omidenepag. The underlying pharmacological mechanism for the multiday extended activity of JV-GL1 is highly intriguing. The present studies were intended to determine EP₂ receptor involvement in mediating the long-term ocular hypotensive activity of JV-GL1 by using mice genetically deficient in EP₂ receptors.

Methods

The protracted IOP reduction produced by JV-GL1 was investigated in C57BL/6J and EP₂

SUBMITTER: Bertrand JA 

PROVIDER: S-EPMC8875279 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature