Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.

ABSTRACT:

Background

The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.

Methods

We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.

Results

Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02)

SUBMITTER: Pechere-Bertschi A 

PROVIDER: S-EPMC8875469 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature