Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141.

ABSTRACT: Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non‒O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulat

SUBMITTER: Hounmanou YMG 

PROVIDER: S-EPMC8888207 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature