Bubble-templated synthesis of nanocatalyst Co/C as NADH oxidase mimic.

ABSTRACT: Designing highly active nanozymes for various enzymatic reactions remains a challenge in practical applications and fundamental research. In this work, by studying the catalytic functions of natural NADH oxidase (NOX), we devised and synthesized a porous carbon-supported cobalt catalyst (Co/C) to mimic NOX. The Co/C can catalyze dehydrogenation of NADH and transfers electrons to O₂ to produce H₂O₂. Density functional theory calculations reveal that the Co/C can catalyze O₂ reduction to H₂O₂ or H₂O considerably. The Co/C can also mediate electron transfer from NADH to heme protein cytochrome c, thereby exhibiting cytochrome c reductase-like activity. The Co/C nanoparticles can deplete NADH in cancer cells, induce i

SUBMITTER: Chen J 

PROVIDER: S-EPMC8897313 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature