Association of monocyte HLA-DR expression over time with secondary infection in critically ill children: a prospective observational study.

ABSTRACT: An impaired immune response could play a role in the acquisition of secondary infections in critically ill children. Human leukocyte antigen-DR expression on monocytes (mHLA-DR) has been proposed as marker to detect immunosuppression, but its potential to predict secondary infections in critically ill children is unclear. We aimed to assess the association between mHLA-DR expression at several timepoints and the change of mHLA-DR expression over time with the acquisition of secondary infections in critically ill children. In this prospective observational study, children < 18 years with fever and/or suspected infection (community-acquired or hospital-acquired) were included at a paediatric intensive care unit in the Netherlands. mHLA-DR expression was determined by flow cytometry on day 1,

SUBMITTER: Hagedoorn NN 

PROVIDER: S-EPMC8897323 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature