Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction and bone erosion. Even if many treatments were developed with success in the last decades, some patients fail to respond, and disease chronicity is still a burden. Mechanisms involved in such resistance may include molecular changes in stromal cells. Other explanations can come from observations of tenosynovial giant cell tumor (TGCT), first considered as an inflammatory arthritis, but with unusual neoplastic features. TGCT leads to synovium hypertrophy and hyperplasia with hemosiderin deposition. It affects young adults, resulting in secondary osteoarthritis and increased morbidity. TGCT shows clinical, histological and genetic similarities with RA but affecting a single joint. However, the monoclo

SUBMITTER: Robert M 

PROVIDER: S-EPMC8899011 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature