Short-term effect of dopaminergic medication on speech in early-stage Parkinson's disease.

ABSTRACT: The effect of dopaminergic medication on speech has rarely been examined in early-stage Parkinson's disease (PD) and the respective literature is inconclusive and limited by inappropriate design with lack of PD control group. The study aims to examine the short-term effect of dopaminergic medication on speech in PD using patients with good motor responsiveness to levodopa challenge compared to a control group of PD patients with poor motor responsiveness. A total of 60 early-stage PD patients were investigated before (OFF) and after (ON) acute levodopa challenge and compared to 30 age-matched healthy controls. PD patients were categorised into two clinical subgroups (PD responders vs. PD nonresponders) according to the comparison of their motor performance based on movement disorder societ

SUBMITTER: Tykalova T 

PROVIDER: S-EPMC8901688 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature