Unknown

Dataset Information

0

Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.

ABSTRACT: To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77-.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81-.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71-1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages.

SUBMITTER: Nyberg T 

PROVIDER: S-EPMC8903446 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages.

Nyberg Tommy T   Harman Katie K   Zaidi Asad A   Seaman Shaun R SR   Andrews Nick N   Nash Sophie G SG   Charlett Andre A   Lopez Bernal Jamie J   Myers Richard R   Groves Natalie N   Gallagher Eileen E   Gharbia Saheer S   Chand Meera M   Thelwall Simon S   De Angelis Daniela D   Dabrera Gavin G   Presanis Anne M AM  

The Journal of infectious diseases 20220901 5

To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77-.94), hospital admission or emergency care att  ...[more]

Similar Datasets

Unknown Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.
| S-EPMC8917961 | biostudies-literature
Unknown SARS-CoV-2 AY.4.2 variant circulating in Italy: Genomic preliminary insight.
| S-EPMC8661725 | biostudies-literature
Unknown No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2.
| S-EPMC8727238 | biostudies-literature
Unknown Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance.
| S-EPMC8503871 | biostudies-literature
Unknown No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway.
| S-EPMC8664610 | biostudies-literature
Unknown SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat.
| S-EPMC8877841 | biostudies-literature
Unknown Dominance of Three Sublineages of the SARS-CoV-2 Delta Variant in Mexico.
| S-EPMC9229647 | biostudies-literature
Unknown SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2.
| S-EPMC9326417 | biostudies-literature
Unknown Impact of SARS-CoV-2 omicron BA.1 and delta AY.4.2 variants on the neutralization by sera of patients treated with different authorized monoclonal antibodies.
| S-EPMC8923034 | biostudies-literature
Unknown Molecular Epidemiology of AY.28 and AY.104 Delta Sub-lineages in Sri Lanka.
| S-EPMC9253541 | biostudies-literature