Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial.

ABSTRACT:

Objective

To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics.

Design

Multicentre, open label, randomised, non-inferiority trial.

Setting

Eight centres in the UK, recruiting from June 2016 to June 2018.

Participants

Women aged ≥18 years with recurrent urinary tract infections, requiring prophylactic treatment.

Interventions

Random assignment (1:1, using permuted blocks of variable length via a web based system) to receive antibiotic prophylaxis or methenamine hippurate for 12 months. Treatment allocation was not masked and crossover between arms was allowed.

Main outcome measure

Absolute difference in incidence of symptoma

SUBMITTER: Harding C 

PROVIDER: S-EPMC8905684 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature