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PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe.


ABSTRACT: The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.

SUBMITTER: Severin GW 

PROVIDER: S-EPMC8907281 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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PET in vivo generators <sup>134</sup>Ce and <sup>140</sup>Nd on an internalizing monoclonal antibody probe.

Severin G W GW   Fonslet J J   Kristensen L K LK   Nielsen C H CH   Jensen A I AI   Kjær A A   Mazar A P AP   Johnston K K   Köster U U  

Scientific reports 20220309 1


The in vivo-generator radionuclides <sup>140</sup>Nd (t<sub>1/2</sub> = 3.4 d) and <sup>134</sup>Ce (t<sub>1/2</sub> = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imagi  ...[more]

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