Ontology highlight
ABSTRACT:
SUBMITTER: Severin GW
PROVIDER: S-EPMC8907281 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Severin G W GW Fonslet J J Kristensen L K LK Nielsen C H CH Jensen A I AI Kjær A A Mazar A P AP Johnston K K Köster U U
Scientific reports 20220309 1
The in vivo-generator radionuclides <sup>140</sup>Nd (t<sub>1/2</sub> = 3.4 d) and <sup>134</sup>Ce (t<sub>1/2</sub> = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imagi ...[more]