Deciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteome.

ABSTRACT: CMV is a major cause of morbidity and mortality in immunocompromised individuals that will benefit from the availability of a vaccine. Despite the efforts made during the last decade, no CMV vaccine is available. An ideal CMV vaccine should elicit a broad immune response against multiple viral antigens including proteins involved in virus-cell interaction and entry. However, the therapeutic use of neutralizing antibodies targeting glycoproteins involved in viral entry achieved only partial protection against infection. In this scenario, a better understanding of the CMV proteome potentially involved in viral entry may provide novel candidates to include in new potential vaccine design. In this study, we aimed to explore the CMV genome to identify proteins with putative transmembrane domain

SUBMITTER: Mancebo FJ 

PROVIDER: S-EPMC8911422 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature