The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study.

ABSTRACT:

Background

Research into the potential utility of plasma-derived circulating cell-free nucleic acids as non-invasive adjuncts to radiological imaging have been occasioned by the invasive nature of brain tumour biopsy. The objective of this study was to determine whether significant differences exist in the plasma transcriptomic profile of glioma patients relative to differences in their tumour characteristics, and also whether any observed differences were representative of synchronously obtained glioma samples and TCGA glioma-derived RNA.

Methods

Blood samples were collected from twenty glioma patients prior to tumour resection. Plasma ccfmRNAs and glioma-derived RNA were extracted and profiled.

Results

BCL2L1, GZMB, HLA-A, IRF1, MYD88, TLR2, and TP53 genes were sign

SUBMITTER: Ita MI 

PROVIDER: S-EPMC8913523 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature