Exocrine pancreas function is impaired in adult relatives of patients with type 1 diabetes.

ABSTRACT:

Aims

Alterations of the exocrine pancreas have been reported in type 1 diabetes, but their contribution to the pathogenesis of the disease is poorly understood. Here, we investigated markers of exocrine pancreas dysfunction in individuals at-risk of developing type 1 diabetes.

Methods

Serum P-amylase and lipase levels were assessed in samples obtained from healthy controls, patients with new onset type 1 diabetes, relatives participating to the TrialNet Pathway to Prevention who were, at blood collection, autoantibody negative or positive for a single autoantibody (low-risk individuals), and positive for multiple autoantibodies (high-risk individuals). Linear mixed models were adopted to estimate variation of pancreatic enzymes among the groups and to evaluate the influence

SUBMITTER: Giovenzana A 

PROVIDER: S-EPMC8917021 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature