Loss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain.

ABSTRACT: Aging is a risk factor for neurodegenerative disease, but precise mechanisms that influence this relationship are still under investigation. Work in Drosophila melanogaster identified the microRNA miR-34 as a modifier of aging and neurodegeneration in the brain. MiR-34 mutants present aspects of early aging, including reduced lifespan, neurodegeneration, and a buildup of the repressive histone mark H3K27me3. To better understand how miR-34 regulated pathways contribute to age-associated phenotypes in the brain, here we transcriptionally profiled the miR-34 mutant brain. This identified that genes associated with translation are dysregulated in the miR-34 mutant. The brains of these animals show increased translation activity, accumulation of protein aggregation markers, and altered autopha

SUBMITTER: Srinivasan AR 

PROVIDER: S-EPMC8920459 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature