Expanding the environmental scope: an environment-wide association study for mental well-being.

ABSTRACT:

Background

Identifying modifiable factors associated with well-being is of increased interest for public policy guidance. Developments in record linkage make it possible to identify what contributes to well-being from a myriad of factors. To this end, we link two large-scale data resources; the Geoscience and Health Cohort Consortium, a collection of geo-data, and the Netherlands Twin Register, which holds population-based well-being data.

Objective

We perform an Environment-Wide Association Study (EnWAS), where we examine 139 neighbourhood-level environmental exposures in relation to well-being.

Methods

First, we performed a generalized estimation equation regression (N = 11,975) to test for the effects of environmental exposures on well-being. Second, to account for

SUBMITTER: van de Weijer MP 

PROVIDER: S-EPMC8920882 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature