Helios expressing regulatory T cells are correlated with decreased IL-2 producing CD8 T cells and antibody diversity in Mozambican individuals living chronically with HIV-1.

ABSTRACT:

Background

Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammation but may also suppress beneficial HIV-1 specific immune responses. We aimed to analyze the profile of Tregs and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1 (PLWH-C).

Results

In PLWH-C, the proportion of total Tregs was positively correlated with the proportion of IL-2⁺CD4 T cells (r = 0.647; p = 0.032) and IL-2⁺

SUBMITTER: Matavele Chissumba R 

PROVIDER: S-EPMC8922818 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature