Ontology highlight
ABSTRACT:
SUBMITTER: Shafer P
PROVIDER: S-EPMC8928448 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Shafer Paul P Kelly Lauren M LM Hoyos Valentina V
Frontiers in immunology 20220303
To redirect T cells against tumor cells, T cells can be engineered <i>ex vivo</i> to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T). Unlike chimeric antigen receptors (CARs), TCRs recognize HLA-presented peptides derived from proteins of all cellular compartments. The use of TCR T cells for adoptive cellular therapies (ACT) has gained increased attention, especially as efforts to treat solid cancers with ACTs have intensified. ...[more]