The Beneficial Effects of Earlier Versus Later Implementation of Intensive Therapy in Type 1 Diabetes.

ABSTRACT:

Objective

The principal aim is to estimate the benefits of earlier versus later implementation of intensive therapy in type 1 diabetes with respect to the long-term risks of progression of a renal (microvascular) and cardiovascular (macrovascular) complication in the Epidemiology of Diabetes Interventions and Complications (EDIC) study.

Research design and methods

Cox proportional hazards regression models estimated the 20-year cumulative incidence (absolute risk) and the 20-year relative risk of cardiovascular disease (CVD) and reduced estimated glomerular filtration rate (eGFR) over the first 20 years of EDIC follow-up as a function of the mean HbA_1c.

Results

A hypothetical patient treated earlier with 10 years of intensive therapy and a mean HbA_1c</

SUBMITTER: Lachin JM 

PROVIDER: S-EPMC8929189 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature