Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis.

ABSTRACT:

Aim

To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients.

Methods

Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls.

Results

Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls (SMD = -0.587, 95%CI = -0.776 to -0.339, p < 0.0001, I ² = 92.3%). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared t

SUBMITTER: Zuin M 

PROVIDER: S-EPMC8930235 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature