TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.

ABSTRACT: Background: TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. Methods and Results: Based on TET1^-/- knockout mice (with deletion of both TET1 and TET1s ) and TET1^cs/cs mice (with deletion of only TET1), we found that TET1s deletion in TET1^-/- mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the ApoE^-/- background mice fed a high-fat diet. Atherosclerotic lesions with Oil red staining were dramatically localized in the aortic arch, a

SUBMITTER: Qu K 

PROVIDER: S-EPMC8935216 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature