Splenic denervation attenuates repeated social defeat stress-induced T-lymphocyte inflammation.

ABSTRACT:

Background

Post-traumatic stress disorder (PTSD) is a devastating psychological disorder. Patients with PTSD canonically demonstrate an increased risk for inflammatory diseases, as well as increased sympathetic tone and norepinephrine (NE) outflow. Yet, the exact etiology and causal nature of these physiologic changes remain unclear. Previously, we demonstrated that exogenous NE alters mitochondrial superoxide in T-lymphocytes to produce a pro-inflammatory T-helper 17 (T_H17) phenotype, and observed similar T_H17 polarization in a preclinical model of PTSD. Therefore, we hypothesized sympathetic-driven neuroimmune interactions could mediate psychological trauma-induced T-lymphocyte inflammation.

Methods

Repeated social defeat stress (RSDS) is a preclinica

SUBMITTER: Elkhatib SK 

PROVIDER: S-EPMC8941638 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature