(Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes.

ABSTRACT: Difluoroalkylated compounds have important applications in pharmaceutical, agrochemical, and materials science. However, efficient methods to construct the alkylCF₂-alkyl bond are very limited, and the site-selective introduction of a difluoromethylene (CF₂) group into an aliphatic chain at the desired position remains challenging. Here, we report an unprecedented example of alkylzirconocene promoted difluoroalkylation of alkyl- and silyl-alkenes with a variety of unactivated difluoroalkyl iodides and bromides under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalk

SUBMITTER: Ren X 

PROVIDER: S-EPMC8943901 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature