The Matrisome Is Associated with Metabolic Reprograming in Stem-like Phenotypes of Gastric Cancer.

ABSTRACT: The extracellular matrix (ECM) is an important regulator of all cellular functions, and the matrisome represents a major component of the tumor microenvironment. The matrisome is an essential component comprising genes encoding ECM glycoproteins, collagens, and proteoglycans; however, its role in cancer progression and the development of stem-like molecular subtypes in gastric cancer is unknown. We analyzed gastric cancer data from five molecular subtypes (n = 497) and found that metabolic reprograming differs based on the state of the matrisome. Approximately 95% of stem-like cancer type samples of gastric cancer were in the high-matrisome category, and energy metabolism was considerably increased in the high-matrisome group. Particularly, high glycosaminoglycan biosynthesis-chondr

SUBMITTER: Sung JY 

PROVIDER: S-EPMC8945874 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature