Neonatal Herpes Simplex Virus Infection: Epidemiology and Outcomes in the Modern Era.

ABSTRACT:

Background

Over the past several decades, there have been advances in diagnosis and treatment of neonatal herpes simplex virus (HSV) disease. There has been no recent comprehensive evaluation of the impact of these advances on the management and outcomes for neonates with HSV.

Methods

Clinical data for initial presentation, treatment, and outcomes were abstracted from medical records of neonates with HSV treated at Seattle Children's Hospital between 1980 and 2016.

Results

One hundred thirty infants with a diagnosis of neonatal HSV were identified. Between 1980 and 2016, high-dose acyclovir treatment for neonatal HSV infection increased from 0% to close to 95%, with subsequent decrease in overall HSV-related mortality from 20.9% to 5.6%. However, even among infants tr

SUBMITTER: Melvin AJ 

PROVIDER: S-EPMC8946680 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature