Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.

ABSTRACT: Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. Apoe-null (Apoe^-/-) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ Apoe^-/- mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL

SUBMITTER: Shi LJ 

PROVIDER: S-EPMC8950324 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature