Landscape of Molecular Crosstalk Perturbation between Lung Cancer and COVID-19.

ABSTRACT:

Background

Lung cancer patients have the worst outcomes when affected by coronavirus disease 2019 (COVID-19). The molecular mechanisms underlying the association between lung cancer and COVID-19 remain unknown. The objective of this investigation was to determine whether there is crosstalk in molecular perturbation between COVID-19 and lung cancer, and to identify a molecular signature, molecular networks and signaling pathways shared by the two diseases.

Methods

We analyzed publicly available gene expression data from 52 severely affected COVID-19 human lung samples, 594 lung tumor samples and 54 normal disease-free lung samples. We performed network and pathways analysis to identify molecular networks and signaling pathways shared by the two diseases.

Results

The in

SUBMITTER: Kuchi A 

PROVIDER: S-EPMC8953719 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature