A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.
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ABSTRACT:
SUBMITTER: Knoedler JR
PROVIDER: S-EPMC8956134 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.
Knoedler Joseph R JR Inoue Sayaka S Bayless Daniel W DW Yang Taehong T Tantry Adarsh A Davis Chung-Ha CH Leung Nicole Y NY Parthasarathy Srinivas S Wang Grace G Alvarado Maricruz M Rizvi Abbas H AH Fenno Lief E LE Ramakrishnan Charu C Deisseroth Karl K Shah Nirao M NM
Cell 20220121 4
Sex hormones exert a profound influence on gendered behaviors. How individual sex hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear. We performed orthogonal, genetically targeted sequencing of four estrogen receptor 1-expressing (Esr1<sup>+</sup>) populations and identified 1,415 genes expressed differentially between sexes or estrous states. Unique subsets of these genes were distributed across all 137 transcriptomically defined Esr1<sup>+</sup> cell type ...[more]
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