A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.

ABSTRACT: Sex hormones exert a profound influence on gendered behaviors. How individual sex hormone-responsive neuronal populations regulate diverse sex-typical behaviors is unclear. We performed orthogonal, genetically targeted sequencing of four estrogen receptor 1-expressing (Esr1⁺) populations and identified 1,415 genes expressed differentially between sexes or estrous states. Unique subsets of these genes were distributed across all 137 transcriptomically defined Esr1⁺ cell types, including estrous stage-specific ones, that comprise the four populations. We used differentially expressed genes labeling single Esr1⁺ cell types as entry points to functionally characterize two such cell types, BNSTpr^Tac1/Esr1 and VMHvl^Cckar/Esr1. We observed th

SUBMITTER: Knoedler JR 

PROVIDER: S-EPMC8956134 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature