Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda.

ABSTRACT:

Background

As human activity alters the planet, there is a pressing need to understand how organisms adapt to environmental change. Of growing interest in this area is the role of epigenetic modifications, such as DNA methylation, in tailoring gene expression to fit novel conditions. Here, we reanalyzed nine invertebrate (Anthozoa and Hexapoda) datasets to validate a key prediction of this hypothesis: changes in DNA methylation in response to some condition correlate with changes in gene expression.

Results

In accord with previous observations, baseline levels of gene body methylation (GBM) positively correlated with transcription, and negatively correlated with transcriptional variation between conditions. Correlations between changes in GBM and transcription, however, were

SUBMITTER: Dixon G 

PROVIDER: S-EPMC8957121 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature