Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.

ABSTRACT:

Background context

Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy.

Purpose

To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy.

Study design/setting

A preclinical randomized animal study.

Methods

Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposu

SUBMITTER: Jin L 

PROVIDER: S-EPMC8957503 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature