Cu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway.

ABSTRACT: In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO₃)₂·3H₂O in the existence of 1,3-H₂bdc, the second assistant ligand (in which 1,3-H₂bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu₂(L)₂(1,3-bdc)(H₂O)₂]n (1). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC₅₀ and MTT assay results indicated that complex 1 had a spectral an

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8958075 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature