Antigen-Presenting B Cells Program the Efferent Lymph T Helper Cell Response.

ABSTRACT: B cells interact with T follicular helper (Tfh) cells in germinal centers (GCs) to generate high-affinity antibodies. Much less is known about how cognate T-B-cell interactions influence Th cells that enter circulation and peripheral tissues. Therefore, we generated mice lacking MHC-II expressing B cells and, by thoracic duct cannulation, analyzed Th cells in the efferent lymph at defined intervals post-immunization. Focusing on gut-draining mesenteric lymph nodes (MLNs), we show that antigen-specific α₄β₇⁺ gut-homing effector Th cells enter the circulation prior to CXCR5⁺PD-1⁺ Tfh-like cells. B cells appear to have no or limited impact on the early generation and egress of gut-homing Th cells but are critical for the subsequent appear

SUBMITTER: Alsen S 

PROVIDER: S-EPMC8959485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature