A Gut Feeling in Amyotrophic Lateral Sclerosis: Microbiome of Mice and Men.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a severely debilitating disease characterized by progressive degeneration of motor neurons. ALS etiology and pathophysiology are not well understood. It could be the consequences of complex interactions among host factors, microbiome, and the environmental factors. Recent data suggest the novel roles of intestinal dysfunction and microbiota in ALS etiology and progression. Although microbiome may indeed play a critical role in ALS pathogenesis, studies implicating innate immunity and intestinal changes in early disease pathology are limited. The gastrointestinal symptoms in the ALS patients before their diagnosis are largely ignored in the current medical practice. This review aims to explore existing evidence of gastrointestinal symptoms and progress

SUBMITTER: Martin S 

PROVIDER: S-EPMC8963415 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature