Optimal timing of radiotherapy following brain metastases surgery.

ABSTRACT:

Background

There is growing evidence supporting the need for a short time delay before starting radiotherapy (RT) treatment postsurgery for most optimal responses. The timing of RT initiation and effects on outcomes have been evaluated in a variety of malignancies, but the relationship remains to be well established for brain metastasis.

Methods

Retrospective study of 176 patients (aged 18-89 years) with brain metastases at a single institution (March 2009 to August 2018) who received RT following surgical resection. Time interval (≤22 and >22 days) from surgical resection to initiation of RT and any potential impact on patient outcomes were assessed.

Results

Patients who underwent RT >22 days after surgical resection had a decreased risk for all-cause mortality of 47

SUBMITTER: Yaghi NK 

PROVIDER: S-EPMC8965066 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature