High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis.

ABSTRACT:

Background

Urothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highly activated in several cancers, including UC. However, accumulated evidence has shown discordance between the Wnt/β-catenin signaling and UC carcinogenesis. Accordingly, we aim to get a better understanding of the molecular characterization of UC, focusing on the Wnt signaling, which may add value to guiding management more precisely.

Patients and methods

Clinical data and pathological features were retrospectively surveyed. The correlations of secreted Frizzled-related protein 2

SUBMITTER: Lai HY 

PROVIDER: S-EPMC8965759 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature