Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs.

ABSTRACT:

Background

Restless legs syndrome is a highly prevalent comorbidity of migraine; however, its genetic contributions remain unclear.

Objectives

To identify the genetic variants of restless legs syndrome in migraineurs and to investigate their potential pathogenic roles.

Methods

We conducted a two-stage genome-wide association study (GWAS) to identify susceptible genes for restless legs syndrome in 1,647 patients with migraine, including 264 with and 1,383 without restless legs syndrome, and also validated the association of lead variants in normal controls unaffected with restless legs syndrome (n = 1,053). We used morpholino translational knockdown (morphants), CRISPR/dCas9 transcriptional knockdown, transient CRISPR/Cas9 knockout (crispants) and gene rescue in one-ce

SUBMITTER: Jiang YJ 

PROVIDER: S-EPMC8966278 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature