Dataset Information

Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality.

ABSTRACT:

Background

Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality.

Methods

After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g (n=6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Participants were divided into four quartiles of ACR. The primary outcome was all-cause mortality, and the secondary outcome was CV mortality. Multivariable Cox proportional hazards models were used.

Results

During a median 7.9 years of follow-up, 3516 (9%) participants died. Compared with the reference group (Q1, ACR <4.171 mg/g), low-grade albuminuria groups were associated with all-cause mortality (Q3, ACR ≥6.211 to <10.010 mg/g, hazard ratio [HR], 1.25 [95% CI, 1.11 to 1.41]; Q4, ACR ≥10.010 mg/g, HR, 1.57 [95% CI, 1.41 to 1.76]) in a multivariable hazards model. A similar pattern was also seen in the association of low-grade albuminuria with CV mortality. Subgroup analyses showed that low-grade albuminuria was also associated with all-cause mortality in the nondiabetic group, nonhypertensive group, and non-CKD group (eGFR ≥60 ml/min per 1.73 m²).

Conclusions

Our findings suggest that low-grade albuminuria is associated with all-cause and CV mortality. Low-grade albuminuria should be monitored, even for patients with low CV risk.

SUBMITTER: Kang M

PROVIDER: S-EPMC8967601 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Publications

Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality.

Kang Minjung M Kwon Soie S Lee Jeonghwan J Shin Jung-Im JI Kim Yong Chul YC Park Jae Yoon JY Bae Eunjin E Kim Eun Young EY Kim Dong Ki DK Lim Chun Soo CS Lee Jung Pyo JP

Kidney360 20211105 1

<h4>Background</h4>Despite interest in low-grade albuminuria and poor clinical outcomes, evidence from a large-scale population is lacking. Therefore, we identified the association of low-grade albuminuria within the normal range with all-cause and cardiovascular (CV) mortality.<h4>Methods</h4>After excluding individuals with urine albumin-creatinine ratio (ACR) ≥30 mg/g (<i>n</i>=6094), this cohort study analyzed 43,396 adults who participated in the National Health and Nutrition Examination Su ...[more]

PMID: 35368577

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Dataset Information

Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality.

Background

Methods

Results

Conclusions

Publications

Albuminuria within the Normal Range Can Predict All-Cause Mortality and Cardiovascular Mortality.

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