A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy.

ABSTRACT: Hydrogen sulfide (H₂S) as an important biological gasotransmitter plays a pivotal role in many physiological and pathological processes. The sensitive and quantitative detection of H₂S level is therefore crucial for precise diagnosis and prognosis evaluation of various diseases but remains a huge challenge due to the lack of accurate and reliable analytical methods in vivo. In this work, we report a smart, H₂S-responsive and depleting nanoplatform (ZNNPs) for quantitative and real-time imaging of endogenous H₂S for early diagnosis and treatment of H₂S-associated diseases. We show that ZNNPs exhibit unexpected NIR conversion (F₁₀₇₀→ F₇₂₀) and ratiometric photoacoustic (PA₆₈₀/PA₉₀₀) signal res

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8967875 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature