Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome.

ABSTRACT:

Study objectives

Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.

Methods

In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a P value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.

Results

Of 246 patients with OHS, 122 (50%) had echoca

SUBMITTER: Masa JF 

PROVIDER: S-EPMC8974388 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature