Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.

ABSTRACT: Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanu

SUBMITTER: Datema MR 

PROVIDER: S-EPMC8974676 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature