Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial.

ABSTRACT:

Background

This trial aimed to determine the efficacy of leucine and/or perindopril in improving physical function in older people with sarcopenia.

Methods

Placebo-controlled, parallel group, double-blind, randomized two-by-two factorial trial. We recruited adults aged ≥ 70 years with sarcopenia, defined as low gait speed (<0.8 m/s on 4 m walk) and/or low handgrip strength (women < 20 kg, men < 30 kg) plus low muscle mass (using sex and body mass index category-specific thresholds derived from normative UK BioBank data) from 14 UK centres. Eligible participants were randomized to perindopril 4 mg or placebo, and to oral leucine powder 2.5 g or placebo thrice daily. The primary outcome was the between-group difference in the short physical performance battery (SPPB) score ove

SUBMITTER: LACE study group 

PROVIDER: S-EPMC8977979 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature